Physiologic versus pathologic hypertrophy: Differences in cardiac rotation and filling
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چکیده
منابع مشابه
Physiologic cardiac hypertrophy corrects contractile protein abnormalities associated with pathologic hypertrophy in rats.
To evaluate the combined effects of cardiac overload imposed by hypertension and by chronic exercise, male and female rats were made hypertensive by unilateral renal artery stenoses and made to exercise in an 8-10-wk swimming program. Sedentary normotensive animals, sedentary hypertensive animals and normotensive animals exposed to the swimming program were also studied. Hypertension was associ...
متن کاملGenetic Expression Profiles During Physiologic and Pathologic Cardiac Hypertrophy and Heart Failure in Rats
Cardiac hypertrophy is a complex and non-homogenous response to various stimuli. In this study, we used high-density oligonucleotide microarray to examine gene expression profiles during physiologic hypertrophy, pathologic hypertrophy, and heart failure in Dahl salt-sensitive rats. There were changes in 404/3160 and 874/3160 genes between physiologic vs. pathologic hypertrophy and the transitio...
متن کاملLocal insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice.
In the present study we determined the long-term effects of persistent, local insulin-like growth factor I (IGF-I) expression on cardiac function in the SIS2 transgenic mouse. Cardiac mass/tibial length was increased in SIS2 mice by 10 wk of age; this cardiac hypertrophy became more pronounced later in life. Peak aortic outflow velocity, a correlate of cardiac output, was increased at 10 wk in ...
متن کاملTRPC channels are necessary mediators of pathologic cardiac hypertrophy.
Pathologic hypertrophy of the heart is regulated through membrane-bound receptors and intracellular signaling pathways that function, in part, by altering Ca(2+) handling and Ca(2+)-dependent signaling effectors. Transient receptor potential canonical (TRPC) channels are important mediators of Ca(2+)-dependent signal transduction that can sense stretch or activation of membrane-bound receptors....
متن کاملDifferences in Cardiac Hypertrophy in Exercise and in Hypoxia.
• It is generally known that effective periods of vigorous exercise produce cardiac hypertrophy in rats' and in other species also. Experience has shown that it is difficult to produce a significant cardiac hypertrophy in normal, healthy dogs by use of a treadmill. This has been observed by the senior author and was mentioned by Eyster as early as 1928. Cardiac hypertrophy produced by exercise ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1996
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(96)80781-9